Subacute Combined Degeneration from Nitrous Oxide Abuse in a Patient with Pernicious Anemia

Subacute combined degeneration caused by nitrous oxide intoxication: case reports.

PURPOSE Case reports with a comprehensive review of the current literature concerning subacute combined degeneration induced by nitrous oxide inhalation. A differential diagnosis should be considered when young patients present with progressive myelopathy because that the misuse of nitrous oxide has potentially serious outcomes. CASES REPORT Three young patients aged from 18 to 24, one male a...

Addisonian Pernicious Anæmia with Subacute Combined Degeneration in an Indian

The irreplaceable image: A patient with subacute degeneration of the spinal cord secondary to pernicious anemia.

A 65-year old man presented with a 6-month history of paresthesia and ataxia in the last two months. His past medical history included a chronic anemia syndrome treated with iron and folic acid during the last 3 months. He had discontinued folic acid because of gastric side effects. Physical examination showed slight pallor and magnetic resonance imaging revealed significant neurologic hyperint...

Nitrous Oxide-induced Subacute Combined Degeneration Presenting with Dystonia and Pseudoathetosis: A Case Report.

PURPOSE Nitrous oxide (N2O) is neurotoxic by interfering with vitamin B12 bioavailability. The clinical picture is indistinguishable to that of subacute combined degeneration (SCD). A movement disorder might occur though it is not a characteristic feature. We report a patient with N2O-induced SCD, exhibiting a combination of different involuntary movements. CASE REPORT A 20-year-old woman pre...

Spinal myoclonus in subacute combined degeneration caused by nitrous oxide intoxication.

A 26-year-old patient developed ascending weakness and paresthesias. Megaloblastic anemia and mildly reduced serum vitamin B12 (B12) concentration were noted. Myoclonus-like muscular contractions appeared over four extremities and in the trunk. She admitted inhaling nitrous oxide (N2O) as a euphoriant repeatedly at party. Following parenteral B12 administration, her neurological deficit promptl...